Publications

Complete List of Published Work at NCBI

• Galkin A. (2020) Water route for proton pumping in mitochondrial complex I. Nat.Stuct.Mol.Biol. PMID: 32826994  DOI: 10.1038/s41594-020-0500-y
• Niatsetskaya Z, Sosunov S, Stepanova A, Goldman J, Galkin A, Neginskaya M, Pavlov E, Ten V. (2020) Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. J.Clin.Invest.  PMID: 32925170 DOI: 10.1172/JCI133082
• Schlegel A, Muller X, Mueller M, Stepanova A, Kron P, de Rougemont O, Muiesan P, Clavien PA, Galkin A, Meierhofer D, Dutkowski P. (2020) Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation. EBioMedicine PMID: 32979838   DOI: 10.1016/j.ebiom.2020.103014.
• Stepanova A, Galkin A. (2020) Measurement of mitochondrial H₂O₂ production under varying O₂ tensions. Methods Cell.Biol. 155, 273-293. PMID: 32183962  DOI: 10.1016/bs.mcb.2019.12.008
• Galkin A (2019) Brain Ischemia/Reperfusion Injury and Mitochondrial Complex I Damage.   Biochemistry (Moscow), 84, 1411-1423. PMID: 31760927  DOI: 10.1134/S0006297919110154

• Ten V and Galkin A. (2019) Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis. Mol Cell Neurosci. 100, 103408. PMID: 31494262    DOI: 10.1016/j.mcn.2019.103408.

• Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. (2019) Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. PMID: 31402314, DOI: 10.1016/j.cmet.2019.07.006
• Niihori M, Eccles CA, Kurdyukov S, Zemskova M, Varghese MV, Stepanova AA, Galkin A, Rafikov R, Rafikova O. (2019) Rats with Human Mutation of NFU1 Develop Pulmonary Hypertension. Am. J. Respir. Cell. Mol. Biol.  PMID: 31461310
• Wojtovich AP, Berry BJ, Galkin A. (2019) Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease. Antioxid Redox Signal. 31, 591-593 PMID: 31084372  doi: 10.1089/ars.2019.7804.
• Hayes L, Asressa S, Li Y, Galkin A, Stepanova A, Kawamata H, Manfredi G, Glass J (2019) Distal denervation in the SOD1 knockout mouse correlates with loss of mitochondria at the motor nerve terminal. Experimental Neurology, 318, 251-257, PMID: 31082391 https://doi.org/10.1016/j.expneurol.2019.05.008
• Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A. (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury.  Antioxid Redox Signal. 31, 608-622.  PMID: 31037949
• Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2019) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem. 148, 731-745,  DOI:  10.1111/jnc.14654  PMID: 30582748
• Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A, Ten V (2018) Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. Free Radic Biol Med. 124, 517-524.  PMID: 30037775.
• Kahl A, Stepanova A, Konrad C, Anderson C, Manfredi G, Zhou P, Iadecola C, Galkin A. (2018) Critical role of flavin and glutathione in Complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury. Stroke. 49, 223-1231.PMID: 29643256
• Sahni PV, Zhang J, Sosunov S, Galkin A, Niatsetskaya Z, Starkov A, Brookes PS, Ten VS. (2018) Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice. Pediatric research. 83, 491-497. PMID: 29211056
• Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A. (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J.Cerebral Blood Flow and Metabolism. 271678X18770331. PMID:29629602
• Sansone P, Savini C, Kurelac I, Chang Q, Amato L, Strillacci A, Stepanova A, Iommarini L,  Mastroleo C, Daly L, Galkin A, Thakur B, Soplop N, Uryu  K, Hoshino A,  Norton L, Bonafe M,  Cricca M,  Gasparre G,  Lyden D, Bromberg J.  (2017) Packaging and transfer of mtDNA via exosomes regulate escape from dormancy in hormonal therapy resistant breast cancer Proc Natl Acad Sci U S A, 114:E9066-E9075. PMID: 29073103
• Stepanova, A., Kahl, A., Konrad, C., Ten, V., Starkov, A, Galkin, A. (2017) Reverse electron transfer results in a loss of flavin from mitochondrial complex I. Potential mechanism for brain ischemia/reperfusion injury, J.Cerebral Blood Flow and Metabolism.  271678 X 17730242.  PMID:28914132
• Lin H, Magrane J, Rattelle A, Stepanova A, Galkin A, Clark E, Dong Y, M. Halawani S, Lynch D. (2017) Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Disease Models & Mechanisms,10:1343-1352. PMID:29125827
• Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J, Levin LR, Manfredi G. (2017) Distinct intracellular sAC-cAMP domains regulate ER calcium signaling and OXPHOS function. J. Cell. Sci. 130:3713-3727. PMID:28864766.
• Suslova TA, Burmistrova AL, Vavilov MN, Chernova MS, Khromova EB, Belyaeva SV, Zaripova ON, Stashkevich DS, Galkin A, Darke C. (2017) HLA gene and haplotype frequencies in a Nagaybaks population from the Chelyabinsk Region (Russian South Urals). Hum. Immunol. 78:595-601. PMID:28844894. 
• Kiprowska M.J., Stepanova A., Todaro D.R., Galkin A., Haas A., Wilson S.M., Figueiredo-Pereira M.E.. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: relevance to Alzheimer's disease. Biochim Biophys Acta., 1863:1157-1170. PMID:28372990 
• Galkin A., Moncada S. (2017) Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention. Interface Focus, 7:20160104. PMID:28382200
• Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A. (2016) Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart. Biochim Biophys Acta. 1857:1561-1568. PMID: 27287543
• Dröse, S., Stepanova A., Galkin A. (2016) Ischemic A/D transition of mitochondrial complex I and its role in ROS generation. Biochim. Biophys. Acta. 1857, 946-957 Hyspler R., Ticha A., Schierbeek H., Galkin A., Zadak Z. (2015) The evaluation and quantitation of dihydrogen metabolism using deuterium isotope in rats. PLoS ONE 10:e0130687. PMID:26103048
• Stepanova A., Valls A., Galkin A. (2015) Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I. Biochim. Biophys. Acta. 1847:1085–1092. PMID:26009015
• Glebova K., Reznik O., Reznik A., Mehta R., Galkin A., Baranova A., Skoblov M. (2014) A potential of siRNA technology in kidney transplantation, BioDrugs  28:345-361 PMID:24573958
• Babot M., Labarbuta P., Birch A., Kew S., Fuszard M., Botting C., Heide H., Wittig I., Galkin A. (2014) ND3, ND1 and 39 kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I. Biochim. Biophys. Acta. 1837:929-939. PMID:24560811
• Babot M., Labarbuta P., Birch A., Galkin A. (2014) Characterisation of the active/deactive transition of mitochondrial complex I. Biochim. Biophys. Acta. 1837:1083-1092. PMID:24569053
• Babot M., Galkin A. (2013) Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I. Biochem. Soc. Trans. 41:1325-1330. PMID:24059527
• Ciano M., Fuszard M., Heide H., Botting C.H., Galkin A. (2013) Conformation-specific crosslinking of mitochondrial complex I. FEBS Lett. 587:867-872. PMID:23454639
• Gorenkova N., Robinson E., Grieve D., Galkin A. (2013) Conformational change of mitochondrial complex I increases ROS sensitivity during ischaemia. Antioxid Redox Signal. 19, 1459-68.  PMID:23419200
• Carey N., Galkin A., Henriksson P., Richards J.G., Sigwart J.D (2013) Variation in oxygen consumption among ‘living fossils’ (Mollusca: Polyplacophora) J Mar Biol Assoc U.K. 93, 197–207. DOI:10.1017/S0025315412000653
• Gostimskaya I., Galkin A. (2010) Preparation of Highly Coupled Rat Heart Mitochondria. Journal of Visual Experiment, DOI: 10.3791/2202I. PMID: 20972393
• Galkin, A., Abramov, A., Frakich, N., Duchen, M., Moncada, S. (2009) Lack of oxygen deactivates mitochondrial complex I: Implications for ischemic injury? J.Biol.Chem., 284: 36055-36061. PMID:19861410.
• Drose S., Galkin A., Brandt, U. (2009). Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica. Methods in Enzymology, 456: 475-490. PMID:19348905.
• Galkin, A., Meyer, B., Wittig, I., Karas, M., Schägger H., Vinogradov, A., Brandt, U. (2008) Identification of the mitochondrial complex I ND3 subunit as a structural component involved in the active/de-active enzyme transition. J.Biol.Chem., 283: 20907-20913. PMID:18502755.
• Galkin, A. and Moncada, S. (2007 )Nitrosation of mitochondrial complex I. J.Biol.Chem., 282: 37448-37453. PMID:17956863.
• Galkin, A., Higgs, A., Moncada, S. (2007) Nitric oxide and hypoxia. Essays in Biochemistry, 43: 29-40. PMID:17705791.
• Galkin, A., Dröse, S., Brandt, U. (2006) The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes. Biochim. Biophys. Acta., 1757:1575-1581. PMID:17094937.
• Galkin, A., Zwicker, K., Dröse, S., Grgic, L., Kerscher, S. and Brandt, U. (2006) The redox-Bohr group associated with iron-sulfur cluster N2 of complex I. J.Biol.Chem., 281:23013-23017. PMID:16760472.
• Dröse, S., Galkin, A., Brandt, U. (2005) Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes. Biochim. Biophys. Acta., 1710:87-95. PMID:16289468.
• Galkin, A. and Brandt, U. (2005) Superoxide radical formation by pure complex I (NADH: Ubiquinone oxidoreductase) from Yarrowia lipolytica. J.Biol.Chem., 280:30129-30135. PMID:15985426.
• Brandt, U., Abdrakhmanova, A., Zickermann, V., Galkin, A., Dröse, S., Zwicker, K., Kerscher, S. (2005) Structure-function relationship in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica. Biochem.Soc.Trans., 33:840-844. PMID:16042611.
• Eschemann A., Galkin, A., Oettmeier, W., Brandt, U., Kerscher, S. (2005) HDQ (1-hydroxy-2-dodecyl-4(1H)-quinolone), a high affinity inhibitor for mitochondrial alternative NADH-dehydrogenase - evidence for a ping-pong mechanism. J.Biol.Chem., 280:3138-3142. PMID:15533932.
• Finikova O., Galkin, A., Cordero, M., Hägerhäll, C., Vinogradov, S. (2003) Dendritic porphyrins and tetrabenzoporphyrins: tunable membrane-impermeable fluorescent pH sensors. J.Am.Chem.Soc., 125:4882 - 4893. PMID:12696908.
• Galkin, A., Grivennikova, V.G., Vinogradov, A.D. (2001) Stoichiometry of the NADH:Ubiquinone reductase reaction catalyzed by mitochondrial Complex I. Biochemistry (Moscow), 66:435-537. PMID:11403652.
• Galkin, A., Grivennikova, V.G., Vinogradov, A.D. (1999) Stoichiometry in NADH-quinone reductase reactions catalyzed by the bovine heart submitochondrial particles. FEBS Lett., 451:157-161. PMID:10371157.